TB-500 (Thymosin Beta-4): Research Guide & Technical Data

What Is TB-500 (Thymosin Beta-4)?

TB-500 is a synthetic version of a region of Thymosin Beta-4 (Tβ4), a naturally occurring 43-amino-acid peptide involved in actin regulation. It is one of the most studied peptides in preclinical tissue-repair and cell-migration research. This guide summarizes its structure, research background, and laboratory handling, provided strictly for research use only (RUO).

Research Background

Thymosin Beta-4 is a major intracellular actin-sequestering peptide. In published preclinical and in-vitro research it has been studied in the context of cell migration, angiogenesis, and connective-tissue and wound-repair models. TB-500 is frequently investigated alongside BPC-157 in comparative repair-model literature. It is not a drug or supplement and is not intended for human or veterinary use.

Technical Data

Compound	TB-500 (Thymosin Beta-4, Tβ4)
CAS Number	77591-33-4
Molecular Formula	C212H350N56O78S
Molecular Weight	≈ 4963.4 g/mol
Active Motif	Actin-binding domain (LKKTETQ)
Form	Lyophilized powder
Purity	99%+ (HPLC / LC-MS verified)

Handling, Storage & Reconstitution (Lab Use)

Lyophilized TB-500 is typically stored at −20 °C, protected from light. Laboratory reconstitution commonly uses bacteriostatic or sterile water; reconstituted peptide is generally refrigerated and used within a limited window. Follow your institution’s handling and biosafety procedures.

Frequently Asked Questions

What is TB-500?

TB-500 is a synthetic fragment/analog of Thymosin Beta-4, an actin-binding peptide studied in preclinical cell-migration and tissue-repair models. It is for research use only.

Is TB-500 the same as Thymosin Beta-4?

TB-500 corresponds to the active region of the full 43-amino-acid Thymosin Beta-4 protein; product listings often use the names interchangeably.

How is TB-500 supplied?

As a lyophilized powder, HPLC/LC-MS tested to 99%+ purity, for research use only.

Buy TB-500 for Research

Zama Biosciences supplies TB-500 (Thymosin Beta-4) 5mg and the BPC-157 + TB-500 Blend, independently HPLC/LC-MS tested. See related compound BPC-157.

Research Use Only. Products referenced are not drugs, supplements, or medical devices, and are not for human or veterinary use, consumption, or diagnostic application. Statements have not been evaluated by the FDA.