IGF-1 LR3: Research Guide & Technical Data

What Is IGF-1 LR3?

IGF-1 LR3 (Long R3 Insulin-like Growth Factor-1) is a synthetic 83-amino-acid analog of native IGF-1, modified for extended stability. It is a widely studied compound in growth-factor and cell-signaling research. This guide summarizes its structure, mechanism, and laboratory handling, provided strictly for research use only (RUO).

Mechanism of Action

IGF-1 LR3 is an analog of IGF-1 that binds the IGF-1 receptor; the “Long R3” modifications reduce binding to IGF-binding proteins, extending its half-life in research systems. In preclinical literature it has been studied in growth-factor-signaling and cell-proliferation models. It is not a drug or supplement and is not intended for human or veterinary use.

Technical Data

Compound	IGF-1 LR3 (Long R3 IGF-1)
CAS Number	946870-92-4
Molecular Weight	≈ 9111 g/mol
Target	IGF-1 receptor
Form	Lyophilized powder
Purity	99%+ (HPLC / LC-MS verified)

Handling, Storage & Reconstitution (Lab Use)

Lyophilized IGF-1 LR3 is typically stored at −20 °C, protected from light. Laboratory reconstitution commonly uses sterile or bacteriostatic water (or dilute acetic acid per protocol); reconstituted material is generally refrigerated and used within a limited window. Follow your institution’s handling and biosafety procedures.

Frequently Asked Questions

What is IGF-1 LR3?

IGF-1 LR3 is a long-acting synthetic analog of IGF-1 studied in preclinical growth-factor-signaling research. It is for laboratory research only.

How does IGF-1 LR3 differ from native IGF-1?

The “Long R3” modifications reduce binding-protein interaction, extending its research half-life compared with native IGF-1.

Buy IGF-1 LR3 for Research

Zama Biosciences supplies IGF-1 / IGF-1 LR3, independently HPLC/LC-MS tested. See related growth-axis compound Tesamorelin.

Research Use Only. Not drugs, supplements, or medical devices; not for human or veterinary use, consumption, or diagnostic application. Not evaluated by the FDA.