MOTS-c: Research Guide, Sequence & Technical Data
What Is MOTS-c?
MOTS-c (Mitochondrial ORF of the twelve S rRNA type-c) is a mitochondrial-derived peptide — a 16-amino-acid peptide encoded within the mitochondrial genome. It is a prominent tool compound in metabolic and mitochondrial research. This guide summarizes its structure, research background, and laboratory handling, provided strictly for research use only (RUO).
Research Background
In published preclinical and in-vitro research, MOTS-c has been studied as a regulator of metabolic homeostasis, including work on AMPK-pathway signaling, cellular energy metabolism, and exercise/metabolic-stress models. MOTS-c is not a drug or supplement and is not intended for human or veterinary use.
Technical Data
| Compound | MOTS-c |
| CAS Number | 1627580-64-6 |
| Molecular Weight | ≈ 2174.6 g/mol |
| Sequence | Met-Arg-Trp-Gln-Glu-Met-Gly-Tyr-Ile-Phe-Tyr-Pro-Arg-Lys-Leu-Arg (MRWQEMGYIFYPRKLR) |
| Class | Mitochondrial-derived peptide (MDP) |
| Form | Lyophilized powder |
| Purity | 99%+ (HPLC / LC-MS verified) |
Handling, Storage & Reconstitution (Lab Use)
Lyophilized MOTS-c is typically stored at −20 °C, protected from light. Laboratory reconstitution commonly uses bacteriostatic or sterile water; reconstituted peptide is generally refrigerated and used within a limited window. Follow your institution’s handling and biosafety procedures.
Frequently Asked Questions
What is MOTS-c?
MOTS-c is a 16-amino-acid mitochondrial-derived peptide studied in preclinical metabolic and mitochondrial-signaling research. It is for laboratory research only.
What pathway is MOTS-c associated with in research?
Research literature associates MOTS-c with AMPK-pathway signaling and cellular energy-metabolism regulation.
Buy MOTS-c for Research
Zama Biosciences supplies MOTS-c in multiple sizes, independently HPLC/LC-MS tested. See related metabolic-research compounds SS-31 (Elamipretide) and SemZama (Semaglutide).
Research Use Only. Products referenced are not drugs, supplements, or medical devices, and are not for human or veterinary use, consumption, or diagnostic application. Statements have not been evaluated by the FDA.