KPV Peptide Research Guide: Melanocortin Anti-Inflammatory Mechanism & Data
What Is KPV?
KPV is a tripeptide composed of lysine, proline, and valine (Lys-Pro-Val), corresponding to the C-terminal fragment (residues 11–13) of alpha-melanocyte-stimulating hormone (α-MSH). Despite its small size, KPV retains much of the anti-inflammatory activity of the parent hormone while lacking its pigmentary (melanogenic) effects, which makes it a widely studied tool compound in inflammation research.
Mechanism & Research Background
KPV’s anti-inflammatory activity is studied through both receptor-dependent and intracellular pathways. It is associated with modulation of the melanocortin system and with downregulation of pro-inflammatory signaling, notably interference with NF-κB activation and reduction of pro-inflammatory cytokine production. Research also indicates KPV can be transported into cells and to sites of inflammation, and studies in intestinal and mucosal models have examined its effect on inflammatory pathways at the cellular level.
Because KPV is the minimal C-terminal message sequence of α-MSH stripped of the melanocortin residues responsible for pigmentation, it is frequently compared with full-length melanocortin agonists such as Melanotan I in receptor-selectivity research. KPV is also a component of copper-peptide anti-inflammatory blends.
Technical Data
| Compound | KPV (Lysine-Proline-Valine) |
| CAS Number | 67727-97-3 |
| Molecular Formula | C₁₆H₃₀N₄O₄ |
| Molecular Weight | 342.44 g/mol |
| Sequence | Lys-Pro-Val (α-MSH 11–13) |
| Form | Lyophilized powder |
| Role | Melanocortin-derived anti-inflammatory peptide |
Handling & Storage
Store lyophilized KPV at −20 °C, protected from light and moisture. Reconstitute in sterile or bacteriostatic water, keep refrigerated at 2–8 °C, and avoid repeated freeze-thaw cycles. As a short tripeptide, KPV is generally water-soluble and stable when properly stored.
Frequently Asked Questions
What is KPV derived from?
It is the C-terminal tripeptide (residues 11–13) of alpha-melanocyte-stimulating hormone (α-MSH).
Does KPV cause pigmentation like Melanotan?
No — KPV lacks the melanocortin core residues responsible for melanogenesis, so it retains anti-inflammatory activity without the pigmentary effects associated with full melanocortin agonists.
Where is KPV used in blends?
KPV is included in copper-peptide anti-inflammatory research blends alongside compounds such as GHK-Cu, BPC-157, and TB-500.
Buy KPV for Research
KPV is available in Zama Biosciences research blends, including the GHK-Cu + KPV Blend and the Klow 80mg Blend (GHK-Cu / BPC-157 / TB-500 / KPV). Browse the full Peptide Research Library for related mechanism guides.
Research Use Only. All products sold by Zama Biosciences are intended strictly for in-vitro laboratory research and are not for human or veterinary use, consumption, or diagnostic purposes. The information on this page is provided for educational purposes and does not constitute medical advice.