Eloralintide (LY3841136): Research Guide, Mechanism & Technical Data

What Is Eloralintide (LY3841136)?

Eloralintide, also known by its research code LY3841136, is a long-acting, highly selective amylin receptor agonist originally developed by Eli Lilly. It has become one of the most closely watched peptides in metabolic research. This guide summarizes what the current literature describes about its structure, mechanism, and laboratory handling. All information below is provided strictly for research use only (RUO).

Mechanism of Action

Eloralintide is a synthetic amylin mimetic that binds the human amylin receptors AMY1R (EC₅₀ ≈ 23.9 pM) and AMY3R (EC₅₀ ≈ 253.8 pM) with high selectivity over the calcitonin receptor. In published preclinical and early clinical research, this selective amylin-receptor activation has been studied in models of appetite regulation, food intake, and body-weight/fat-mass endpoints. It is frequently compared with other amylin-pathway compounds such as cagrilintide.

Research Applications

In the research setting, eloralintide is studied as a tool compound for investigating amylin-receptor signaling and metabolic pathways. Reported areas of scientific interest include appetite and satiety signaling, energy-balance models, and comparative pharmacology against GLP-1 and dual-agonist compounds. Eloralintide is not a drug, supplement, or therapeutic product and is not intended for human or animal use.

Technical Data

Compound	Eloralintide (LY3841136)
CAS Number	2883634-40-8
Molecular Formula	C201H319N49O65S2
Molecular Weight	≈ 4526.1 g/mol
Target	Selective amylin receptor (AMY1R / AMY3R) agonist
Form	Lyophilized powder
Purity	99%+ (HPLC / LC-MS verified)

Handling, Storage & Reconstitution (Lab Use)

As with most lyophilized research peptides, eloralintide is typically stored at −20 °C and protected from light, with long-term stability best preserved in a frost-free freezer. For laboratory reconstitution, bacteriostatic or sterile water is commonly used; reconstituted solutions are generally kept refrigerated and used within a limited window. Always follow your institution’s handling and biosafety procedures.

Frequently Asked Questions

What is eloralintide used for?

In research, eloralintide is used as a selective amylin-receptor agonist tool compound for studying metabolic and appetite-signaling pathways. It is for laboratory research only.

What is the difference between eloralintide and cagrilintide?

Both act on the amylin pathway, but eloralintide (LY3841136) is described as a highly selective amylin-receptor agonist, whereas cagrilintide is a dual amylin/calcitonin receptor agonist.

How is eloralintide supplied?

It is supplied as a lyophilized powder, HPLC/LC-MS tested for 99%+ purity, for research use only.

Buy Eloralintide for Research

Zama Biosciences supplies EloraZama (Eloralintide / LY3841136) as a lyophilized research peptide, independently HPLC/LC-MS tested. See related amylin-pathway compounds including Cagrilintide and MOTS-c.

Research Use Only. Products referenced are not drugs, supplements, or medical devices, and are not for human or veterinary use, consumption, or diagnostic application. Statements have not been evaluated by the FDA.